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https://www.drugs.com/paracetamol.html
Feb 16, 2021 · General Dosing Guidelines: 325 to 650 mg every 4 to 6 hours or 1000 mg every 6 to 8 hours orally or rectally. Paracetamol 500mg tablets: Two 500 mg tablets orally every 4 to 6 hours. Usual Adult Paracetamol Dose for Pain: General Dosing Guidelines: 325 to 650 mg every 4 to 6 hours or 1000 mg every 6 to 8 hours orally or rectally.
https://en.wikipedia.org/wiki/Paracetamol_poisoning
The concentration in serum after a typical dose of paracetamol usually peaks below 30 mg/l, which equals 200 μmol/L. Levels of 30–300 mg/L (200–2000 μmol/L) are often observed in overdose patients. Postmortem blood levels have ranged from 50 to 400 mg/L in persons dying due to acute overdosage.
https://en.wikipedia.org/wiki/Paracetamol
Paracetamol's bioavailability is dose-dependent: it increases from 63% for 500 mg dose to 89% for 1000 mg dose. Its plasma terminal elimination half-life is 1.9–2.5 hours, [4] and volume of distribution is roughly 50 L. [115] Protein binding is negligible, except under the conditions of overdose, when it may reach 15–21%. [4]
https://pubchem.ncbi.nlm.nih.gov/compound/acetaminophen
Acetaminophen (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO).It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the U.S. FDA in 1951 and is available in a variety of forms including syrup form ...
https://bnf.nice.org.uk/medicinal-forms/paracetamol.html
Do not take more than 8 in 24 hours . Label 30 - Contains paracetamol. Do not take anything else containing paracetamol while taking this medicine. Talk to a doctor at once if you take too much of this medicine, even if you feel well ... Paracetamol 24 mg per 1 ml; 2000: ml (P) £23.80 Part VIIIA Category C: £23.80: Paracetamol 120mg/5ml oral ...
https://go.drugbank.com/drugs/DB00316
The half-life for adults is 2.5 h after an intravenous dose of 15 mg/kg. Label After an overdose, the half-life can range from 4 to 8 hours depending on the severity of injury to the liver, as it heavily metabolizes acetaminophen. 9. Clearance. Adults: 0.27 L/h/kg following a 15 mg/kg intravenous (IV) dose.
https://www.medicines.org.uk/emc/product/10817/smpc
Take 500 mg to 1000 mg at a time, up to 3000 mg per 24 hours. The maximum daily dose of Paracetamol must not exceed 3000 mg. Children 10 to 15 years of age (40-55 kg body weight) Take 500 mg at a time, up to 2000 mg per 24 hours. The daily dose must not exceed 2000 mg. Not recommended for …
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(19)30066-5/fulltext
May 02, 2019 · Two hours before the end of this 12 h treatment regimen blood was drawn and NAC treatment was stopped after 12 h if the following criteria were satisfied: INR 1.3 or less; and alanine transaminase activity (ALT) < 100 U/L and not more than doubled from admission; and paracetamol concentration < 20 mg/L. If these criteria were not reached then ...
https://quizlet.com/327031970/dosage-exam-practice-30-qs-15-hours-flash-cards/
48. The physician orders Keflex 300 mg po q 8 h for a child who weighs 34 lb. Keflex is supplied in an oral suspension of 125 mg/5 mL. The recommended daily oral dosage for a child is 50 to 100 mg/kg/24 h divided q 8 h. a. Child's weight is _____ kg. b. How many milligrams per kilogram per 24 hours …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445139/
May 26, 2017 · In the late 1970s, most women maintained their intake during pregnancy at an average of about 190 mg/day 3 . In the 1980s and 1990s, the average maternal caffeine consumption declined to about 125 mg/day . Consumption was reported to be about 123 mg/day between 1997 and 2007 (84, 85) and was even lower (58 mg/day) in a 1999 survey .
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